PhD candidate (FPI fellowship) | CBMSO, Madrid

PhD candidate (FPI fellowship)

 Centro de Biología Molecular Severo Ochoa (CBMSO), Madrid

We are looking for a highly motivated PhD thesis candidate in Antonio Alcami´s laboratory.

We offer a 4-year Predoctoral contract linked to project PID2021-128580OB-I00.

 

Description of the project in the field of viral immune evasion:

Poxviruses, such as the viruses causing monkeypox or mousepox, have evolved numerous strategies to modulate different aspects of the host immune response. We study the molecular mechanisms of poxvirus secreted receptors for Interferon or TNF to neutralize the action of these proinflammatory cytokines, and other viral molecules that inhibit DNA sensing host responses. We use the mousepox model of infection to determine the impact of these viral immunomodulators on viral pathogenesis. This is a good opportunity to study viral evasion from the encoding gene to its impact on disease.

 

Requirements:

  • Graduate in studies and a Master related to biomedical sciences: Biochemistry, Biology, Biotechnology.
  • Academic record with average grade over 7.5.
  • Research experience (TFG or TFM) in virology or immunology is desirable.
  • Experience with animal models or an animal handling course is an advantage.
  • Good communication skills in written and oral English will be essential.

 

 Our latest selected publications in this area:

Hernaez et al. (2023). The Lancet Microbe. Jan;4(1):e21-e28. (IF: 86.2).

Alvarez-de Miranda et al. (2021). Pathogens. 10, 1065. (IF:4.5).

Lopez-Muñoz et al (2021). Plos Pathogens. 17(8): e1009541. (IF:7).

Hernaez and Alcami (2020). Current Opinion in Immunology. (IF:7.5).

Alcami. (2020). Science. 369(6502):376-377. (IF:63).

Hernaez et al (2020). Science Advances. 6: eabb4565. (IF:14.1).

 

For more information:  @iviromics and www.cbm.uam.es/antonio_alcami

If you are interested send your CV, academic records and the name/contact address of 2-3 referees to Antonio Alcamí (aalcami@cbm.csic.es)

Oferta Contrato predoctoral FPI CSIC-INIA

Contrato predoctoral FPI CSIC-INIA

Buscamos candidatos para un contrato predoctoral de 4 años de duración asociado al proyecto PID2021-122825OB

«Factores moleculares de restricción en la vía endocítica e interferencia global de los sistemas celulares por el virus de la Peste porcina africana»

del Programa de Generación de Conocimiento del Ministerio de Ciencia e Innovación en el Departamento de Biotecnología del INIA-CSIC, laboratorio de Interacción virus-célula.

Los objetivos del proyecto son el estudio global de las proteínas de interacción del VPPA y otros virus emergentes en las primeras fases de la infección. Estudiamos del control ejercido por los virus en las funciones y sistemas celulares usando proteómica, espectrometría de masas y screening con CRISPR/Cas. Comparamos dianas comunes a diversos virus altamente patógenos como el virus Ébola y SARS-CoV-2. La identificación de las dianas celulares cruciales para la infección, se utilizará para el desarrollo de moléculas antivirales.

Puedes encontrar publicaciones del grupo relacionadas:

  • Cuesta-Geijo et al, 2022. New insights into the role of endosomal proteins for African swine fever virus infection Plos Pathogens 18: e1009784 IF 6.8 https://doi.org/10.1371/journal.ppat.1009784
  • Garcia-Dorival et al, 2021. Identification of Niemann-Pick C1 protein as a potential novel SARS-CoV-2 intracellular target. Antiviral Research 194: 105167-77 IF 10  https://doi.org/10.1016/j.antiviral.2021.105167
  • Lasala et al, 2021. Identification of putative inhibitors of protein- protein interaction useful to fight against Ebola and other highly pathogenic viruses Antiviral Research 186: 105011-5 IF 10. https://doi.org/10.1016/j.antiviral.2021.105011
  • Morales- Tenorio et al, 2021. Potential pharmacological strategies targeting the Niemann-Pick C1 receptor and Ebola virus glycoprotein interaction. European Journal of Medicinal Chemistry 223: 113654-113666. IF 6.51
  • Barrado-Gil et al, 2021. African swine fever virus ubiquitin-conjugating enzyme is an immunomodulator targeting NF-κB activation Viruses13, 1160 IF 5.08 https://doi.org/10.3390/v13061160
  • Galindo et al, 2021. Identification of putative inhibitors of protein- protein interaction useful to fight against Ebola and other highly pathogenic viruses. Antiviral Research 186: 104990 IF 10 https://doi.org/ 10.1016/j.antiviral.2020.104990

 

Requisitos:

  • Titulación universitaria en Bioquímica, Biología, Biotecnología, Químicas, o ciencias de la salud: Veterinaria, Farmacia, Medicina, etc.
  • Estar matriculado en un Master Universitario o poseer el título de Master.
  • Tener experiencia en el laboratorio en técnicas de biología molecular, virología, cultivos celulares, etc.
  • Dominio del idioma inglés conversacional y escrito.

 

Enviar el CV, certificado académico, y/o contactos de referencia, y/o carta de motivación a la directora de la tesis doctoral, Covadonga Alonso a la mayor brevedad.

El plazo de presentación de instancias para los candidatos, estará abierto del 12-26 de enero de 2023.

Contacto: Covadonga Alonso calonso@inia.csic.es

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PhD contract FPI fellowship

 We are seeking for candidates for a PhD contract for 4 years associated to the project PID2021-122825OB

The project focuses in a global study of the interactome of African swine fever virus (ASFV) and other emerging viruses of concern at early infection. We study how viruses manipulate cellular functions and systems using proteomics, mass spectrometry and CRISPR/Cas screening. We compare molecular targets that are shared by several highly pathogenic viruses as Ebola virus and SARS-CoV2. The identification of crucial targets for infection is used to develop antiviral compounds.

Some links to related publications of the group:

  • Cuesta-Geijo et al, 2022. New insights into the role of endosomal proteins for African swine fever virus infection Plos Pathogens 18: e1009784 IF 6.8 https://doi.org/10.1371/journal.ppat.1009784
  • Garcia-Dorival et al, 2021. Identification of Niemann-Pick C1 protein as a potential novel SARS-CoV-2 intracellular target. Antiviral Research 194: 105167-77 IF 10  https://doi.org/10.1016/j.antiviral.2021.105167
  • Lasala et al, 2021. Identification of putative inhibitors of protein- protein interaction useful to fight against Ebola and other highly pathogenic viruses Antiviral Research 186: 105011-5 IF 10. https://doi.org/10.1016/j.antiviral.2021.105011
  • Morales- Tenorio et al, 2021. Potential pharmacological strategies targeting the Niemann-Pick C1 receptor and Ebola virus glycoprotein interaction. European Journal of Medicinal Chemistry 223: 113654-113666. IF 6.51
  • Barrado-Gil et al, 2021. African swine fever virus ubiquitin-conjugating enzyme is an immunomodulator targeting NF-κB activation Viruses13, 1160 IF 5.08 https://doi.org/10.3390/v13061160
  • Galindo et al, 2021. Identification of putative inhibitors of protein- protein interaction useful to fight against Ebola and other highly pathogenic viruses. Antiviral Research 186: 104990 IF 10 https://doi.org/ 10.1016/j.antiviral.2020.104990

 

Requisites

  • A degree in Biochemistry, Biology, Biotechnology, Chemistry, and other health sciences Pharmacy, Veterinary, Medicine, etc.
  • A master in biomedical sciences, graduated or ongoing.
  • Laboratory experience in molecular biology, virology, cell culture, etc. will be assets.
  • High level of English (conversational and written).

The call for applicants will open from January 12-26, 2023.

Send CV, academic degrees or equivalent, referee names, motivation letter, etc.

Applicants contact urgently with the group Director, Covadonga Alonso at calonso@inia.csic.es

 

3 years Postdoctoral position: African Swine Fever Research line (IRTA-CReSA)

Application process

If you wish to be considered for this position, please, apply via our Recruitment Platform (https://www.irta.cat/es/trabajo/) to the job post with reference 144-22 (see attached PDF).

Candidate requirements:

We invite applications from ambitious candidates with relevant research experience and passion to conduct research and innovation activities on the development of vaccines against African swine fever virus and characterization of the immune mechanisms involved in protection.

Required skills:

Teamwork, PhD supervision, Communication, Good written and spoken English, Experience in laboratory practice, Initiative, Planning and organizing.

For more information, send a motivation letter and your CV to: fernando.rodriguez@irta.cat and jordi.argilaguet@irta.cat

Deadline for application: 20/11/2022

Thesis in Animal Health and Veterinary Immunology at IRTA

Project title: Combining ImmunostimulatoryApproaches to improve Animal Health

Aim: To develop ImmunostimulatoryApproaches to reduce the use of antibiotics in livestock by optimizing the animal immune status and improving vaccine efficiencies.

Candidate requirements:

We seek highly motivated and enthusiastic candidates with Graduate studies related to Biomedicine and/or Animal Health. They will be integrated into the PhD Program in Animal Health of the Veterinary School (UAB, Barcelona).

Required skills:

Teamwork, Communication, Good written and spoken English, Experience in laboratory practice, Initiative, Planning and organizing.

To apply, send a motivation letter and a CV (including contact details of 2 referees) to: elena.garcia@irta.cat and fernando.rodriguez@irta.cat

 

Oferta de contrato de trabajo en Biología Molecular y Virología

Oferta de contrato de trabajo en Biología Molecular y Virología en el Área de I+D Biología Molecular de la empresa Algenex en Tres Cantos, Madrid.

 

Se requiere una Licenciatura/Grado en Ciencias de la Vida. Se valorarán el título de Doctor y la experiencia en el laboratorio de virología, en particular el manejo de cultivos celulares y con baculovirus.

 

Información en el documento adjunto.

Oferta de 2 contratos de Titulado Superior en el Instituto de Hortofruticultura Subtropical y Mediterránea «La Mayora» (IHSM UMA CSIC, Algarrobo Costa, Málaga)

El Grupo Interacción Virus de Plantas Insectos Vectores del Instituto de Hortofruticultura Subtropical y Mediterránea «La Mayora» (IHSM UMA CSIC, Algarrobo Costa, Málaga) ofrece 2 contratos de Titulado Superior de un año de duración, ampliables a dos años, asociados a los proyectos:

1. «Profundización en la comprensión y descubrimiento de potenciales nuevos actores en las interacciones entre virus de plantas y el vector mosca blanca (Plan Estatal I+D+i)».

2. «Emerging viral diseases in tomatoes and cucurbits: implementation of mitigation strategies for durable disease management VIRTIGATION (European Union H2020)».

Los interesados deben enviar una carta de motivación y su CV al Investigador Principal de ambos proyectos, Jesús Navas Castillo (jnavas@eelm csic es).

Más información en archivo adjunto.

Oferta de contrato postdoctoral para estudiar la evolución in vitro de resistencia a antivirales en coronavirus causantes del resfriado común (HCoV-229E, HCoV-OC43)

Se ofrece contrato postdoctoral para estudiar la evolución in vitro de resistencia a antivirales en coronavirus causantes del resfriado común (HCoV-229E, HCoV-OC43). Es imprescindible que el/la candidato/a presente experiencia con ensayos de transfección celular y de expresión ectópica de genes en líneas celulares de mamífero. La experiencia en citometría de flujo, análisis de datos de secuenciación masiva, sistemas de microfluidos o trabajando en nivel P2 será bien valorada. El contrato se integra dentro del consorcio PANGREEN-CM basado en el Centro de Biotecnología y Genómica de Plantas (CBGP, UPM/INIA-CSIC), y será por 1 año en primera instancia. El/la candidato/a llevará a cabo ensayos de infección y evolución in vitro, y supervisará a un ayudante de investigación. Fecha de incorporación: 1 de febrero de 2022. Interesados enviar un correo electrónico con asunto «postdoc-PANGREEN», CV y breve expresión de interés al Dr. Alejandro Couce (a.couce@upm.es).

Offer for a 2-year post-doc position

Job offer: Post-doc position (2 years, subject to positive assessment after 1st year) at the Department of Animal Health, Veterinary Faculty, Universitat Autònoma of Barcelona. Veterinary Faculty of Barcelona is a top 10 institution in this area according to the 2021 Shangai’s Global Academic Ranking of Academic Subjects (https://www.shanghairanking.com/rankings/gras/2021/RS0304)

We are seeking a recent PhD (preferably, in virology, viral immunology, or infectious diseases of livestock). Candidates must show a proven record of (one or more of the following):

1. Immunology of human or animal pathogens, preferable viruses of pigs.

2. Virology, with a focus on important viral pathogens of humans or livestock, preferably pigs.

3. Animal experimentation with livestock species.

The candidate must be proficient in basic techniques such as isolation, production, and titration of viruses, viral neutralization, etc. and, additionally in one of the following: a) cellular immunology techniques (ELISPOT, flow cytometry, etc.) or, b) advanced virological techniques or, c) molecular biology applied to virology.

The successful candidate(s) will integrate into a project on the determinants of the evolution of swine influenza viruses in endemically infected pig farms.

The successful candidate(s) will also be expected to do some supervision of trainees (graduate students) and laboratory technicians.

The starting salary will be commensurate with similarpost-docpositions in Spain. Interested candidates are asked to contact Prof. Enric Mateu (enric.mateu@uab.cat) for further details on the conditions of the positions and on how to apply.

The position will be open until late January 2022.

Postdoctoral Research Fellow in Molecular Virology

Postdoctoral Research Fellow in Molecular Virology
University of Surrey – School of Biosciences & Medicine
Location: Guildford
Salary: £32,817 to £38,017 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 7th July 2021
Closes: 31st July 2021
Job Ref: 038421

El grupo de Virología Molecular de la University of Surrey (United Kingdom) está ofreciendo una plaza de postdoc por 3 años en virologia. La oferta es para un postdoc interesado en inmunidad innata y su regulación por virus y el sistema ubiquitina. La plaza está financiada por BBSRC para 3 años en el Maluquer Lab de la University of Surrey (United Kingdom) (www.maluquerlab.org).

Toda la información relevante, incluidos los requisitos y el formulario para la solicitud, se puede encontrar en el siguiente link: https://www.jobs.ac.uk/job/CHI697/postdoctoral-research-fellow-in-molecular-virology

La fecha límite para enviar solicitudes finaliza el 31 de Julio. Los candidatos pre-seleccionados serán contactados posteriormente para encontrar una fecha idónea para formalizar una entrevista vía zoom a partir del 16 de Agosto. La fecha de inicio del proyecto es el 1 de Octubre, aunque se puede retrasar si las necesidades lo requieren.

Para cualquier duda, contactar directamente con Carlos Maluquer (c.maluquerdemotes@surrey.ac.uk).