Contrato predoctoral FPI CSIC-INIA
Buscamos candidatos para un contrato predoctoral de 4 años de duración asociado al proyecto PID2021-122825OB
«Factores moleculares de restricción en la vía endocítica e interferencia global de los sistemas celulares por el virus de la Peste porcina africana»
del Programa de Generación de Conocimiento del Ministerio de Ciencia e Innovación en el Departamento de Biotecnología del INIA-CSIC, laboratorio de Interacción virus-célula.
Los objetivos del proyecto son el estudio global de las proteínas de interacción del VPPA y otros virus emergentes en las primeras fases de la infección. Estudiamos del control ejercido por los virus en las funciones y sistemas celulares usando proteómica, espectrometría de masas y screening con CRISPR/Cas. Comparamos dianas comunes a diversos virus altamente patógenos como el virus Ébola y SARS-CoV-2. La identificación de las dianas celulares cruciales para la infección, se utilizará para el desarrollo de moléculas antivirales.
Puedes encontrar publicaciones del grupo relacionadas:
- Cuesta-Geijo et al, 2022. New insights into the role of endosomal proteins for African swine fever virus infection Plos Pathogens 18: e1009784 IF 6.8 https://doi.org/10.1371/journal.ppat.1009784
- Garcia-Dorival et al, 2021. Identification of Niemann-Pick C1 protein as a potential novel SARS-CoV-2 intracellular target. Antiviral Research 194: 105167-77 IF 10 https://doi.org/10.1016/j.antiviral.2021.105167
- Lasala et al, 2021. Identification of putative inhibitors of protein- protein interaction useful to fight against Ebola and other highly pathogenic viruses Antiviral Research 186: 105011-5 IF 10. https://doi.org/10.1016/j.antiviral.2021.105011
- Morales- Tenorio et al, 2021. Potential pharmacological strategies targeting the Niemann-Pick C1 receptor and Ebola virus glycoprotein interaction. European Journal of Medicinal Chemistry 223: 113654-113666. IF 6.51
- Barrado-Gil et al, 2021. African swine fever virus ubiquitin-conjugating enzyme is an immunomodulator targeting NF-κB activation Viruses13, 1160 IF 5.08 https://doi.org/10.3390/v13061160
- Galindo et al, 2021. Identification of putative inhibitors of protein- protein interaction useful to fight against Ebola and other highly pathogenic viruses. Antiviral Research 186: 104990 IF 10 https://doi.org/ 10.1016/j.antiviral.2020.104990
Requisitos:
- Titulación universitaria en Bioquímica, Biología, Biotecnología, Químicas, o ciencias de la salud: Veterinaria, Farmacia, Medicina, etc.
- Estar matriculado en un Master Universitario o poseer el título de Master.
- Tener experiencia en el laboratorio en técnicas de biología molecular, virología, cultivos celulares, etc.
- Dominio del idioma inglés conversacional y escrito.
Enviar el CV, certificado académico, y/o contactos de referencia, y/o carta de motivación a la directora de la tesis doctoral, Covadonga Alonso a la mayor brevedad.
El plazo de presentación de instancias para los candidatos, estará abierto del 12-26 de enero de 2023.
Contacto: Covadonga Alonso calonso@inia.csic.es
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PhD contract FPI fellowship
We are seeking for candidates for a PhD contract for 4 years associated to the project PID2021-122825OB
The project focuses in a global study of the interactome of African swine fever virus (ASFV) and other emerging viruses of concern at early infection. We study how viruses manipulate cellular functions and systems using proteomics, mass spectrometry and CRISPR/Cas screening. We compare molecular targets that are shared by several highly pathogenic viruses as Ebola virus and SARS-CoV2. The identification of crucial targets for infection is used to develop antiviral compounds.
Some links to related publications of the group:
- Cuesta-Geijo et al, 2022. New insights into the role of endosomal proteins for African swine fever virus infection Plos Pathogens 18: e1009784 IF 6.8 https://doi.org/10.1371/journal.ppat.1009784
- Garcia-Dorival et al, 2021. Identification of Niemann-Pick C1 protein as a potential novel SARS-CoV-2 intracellular target. Antiviral Research 194: 105167-77 IF 10 https://doi.org/10.1016/j.antiviral.2021.105167
- Lasala et al, 2021. Identification of putative inhibitors of protein- protein interaction useful to fight against Ebola and other highly pathogenic viruses Antiviral Research 186: 105011-5 IF 10. https://doi.org/10.1016/j.antiviral.2021.105011
- Morales- Tenorio et al, 2021. Potential pharmacological strategies targeting the Niemann-Pick C1 receptor and Ebola virus glycoprotein interaction. European Journal of Medicinal Chemistry 223: 113654-113666. IF 6.51
- Barrado-Gil et al, 2021. African swine fever virus ubiquitin-conjugating enzyme is an immunomodulator targeting NF-κB activation Viruses13, 1160 IF 5.08 https://doi.org/10.3390/v13061160
- Galindo et al, 2021. Identification of putative inhibitors of protein- protein interaction useful to fight against Ebola and other highly pathogenic viruses. Antiviral Research 186: 104990 IF 10 https://doi.org/ 10.1016/j.antiviral.2020.104990
Requisites
- A degree in Biochemistry, Biology, Biotechnology, Chemistry, and other health sciences Pharmacy, Veterinary, Medicine, etc.
- A master in biomedical sciences, graduated or ongoing.
- Laboratory experience in molecular biology, virology, cell culture, etc. will be assets.
- High level of English (conversational and written).
The call for applicants will open from January 12-26, 2023.
Send CV, academic degrees or equivalent, referee names, motivation letter, etc.
Applicants contact urgently with the group Director, Covadonga Alonso at calonso@inia.csic.es